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Labnics Automated NGS System NNGS-101


Automated NGS System NNGS-101 – Genomic Workflow Automation Equipment

What is NNGS-101 Automated NGS System?

NNGS-101 is a medium-to-high throughput automated next-generation sequencing (NGS) library preparation system that processes DNA, RNA, and cDNA samples into sequencing-ready libraries through automated fragmentation, adapter ligation, amplification, and purification.


Quick Answer 

Automated NGS System NNGS-101 is a laboratory instrument that automates DNA and RNA library preparation for next-generation sequencing by performing fragmentation, adapter ligation, PCR amplification, and magnetic bead purification in a controlled workflow.


Key Takeaways

  • Automates NGS library preparation workflow

  • Supports DNA, RNA, and cDNA processing

  • Handles up to 192 samples per run

  • Reduces manual handling and contamination risk

  • Compatible with standard NGS sequencing platforms

  • Used in research, clinical, and biotech laboratories


What Is NNGS-101 Used For?

NNGS-101 is used to convert biological samples into sequencing-ready libraries for:

  • Whole genome sequencing (WGS)

  • RNA sequencing (RNA-seq)

  • Targeted gene sequencing

  • Molecular diagnostics

  • Pathogen detection and surveillance

  • Gene expression studies

It ensures consistent library quality across multiple samples while reducing manual variability.


How Does NNGS-101 Work? 

Step 1: Sample Loading

DNA, RNA, or cDNA samples are loaded into the system.

Step 2: Fragmentation

Nucleic acids are fragmented into controlled sizes.

Step 3: End Repair & Adapter Ligation

DNA ends are repaired and sequencing adapters are attached.

Step 4: PCR Amplification

Libraries are amplified to increase yield.

Step 5: Magnetic Bead Purification

Unwanted fragments are removed using bead-based purification.

Step 6: Output Generation

Sequencing-ready libraries are collected for downstream analysis.


Why is NNGS-101 Important? (Problem → System → Outcome)

Problem

Manual library preparation is time-consuming, error-prone, and inconsistent.

System

NNGS-101 automates all major library preparation steps.

Outcome

  • Higher reproducibility

  • Lower contamination risk

  • Faster turnaround time

  • Scalable sequencing workflows


Core Functional Capabilities

  • Automated liquid handling system

  • Multi-protocol programmable workflows

  • Integrated thermal cycling module

  • Magnetic bead purification system

  • Sample tracking and barcoding support

  • Compatibility with NGS sequencing platforms


Technical Specifications

Parameter

Specification

Sample Input Range

5 pg – 2 µg

Throughput

24–192 samples/run

Workflow Time

3–5 hours

Reaction Volume

10–100 µL

Purification Method

Magnetic bead-based

Temperature Control

Integrated thermal module

Interface

Digital touchscreen

Power Supply

220 V AC, 50 Hz

Weight

~20 kg


Industries That Use NNGS-101

  • Pharmaceutical research laboratories

  • Biotechnology companies

  • Clinical diagnostics centers

  • Genomics sequencing facilities

  • Public health laboratories

  • Academic research institutions


When Should You Choose NNGS-101?

Choose NNGS-101 if you need:

  • Medium to high throughput sequencing workflows

  • Automation beyond entry-level systems (NNGS-100)

  • Higher sample capacity (up to 192 runs)

  • Balanced workflow speed and flexibility

  • Clinical or regulated research compatibility


Comparison of NGS Systems

Feature

NNGS-100

NNGS-101

NNGS-102

Throughput

16–96

24–192

48–384

Automation Level

Basic

Advanced

Full automation

Input Range

10 pg–1 µg

5 pg–2 µg

5 pg–5 µg

Workflow Time

2–4 hrs

3–5 hrs

4–6 hrs

Use Case

Small labs

Mid-high labs

Large sequencing centers


Applications 

  • Whole genome sequencing (WGS)

  • RNA sequencing (RNA-seq)

  • Targeted sequencing panels

  • Infectious disease surveillance

  • Cancer genomics research

  • Gene expression profiling


Frequently Asked Questions 

1.What does NNGS-101 do?

It automates DNA and RNA library preparation for next-generation sequencing workflows.

2.What samples can it process?

It processes DNA, RNA, and cDNA samples for sequencing applications.

3.How many samples can it handle?

It supports 24–192 samples per run depending on configuration.

4.How long does a run take?

Typical workflow duration is 3–5 hours.

5.Does it support low-input samples?

Yes, it supports picogram-level DNA and RNA inputs.

6.Is it compatible with sequencing platforms?

Yes, it generates libraries compatible with standard NGS systems.

7.What applications is it used for?

It is used in WGS, RNA-seq, targeted sequencing, and molecular diagnostics.


Compliance & Standards

  • CLIA-aligned workflows

  • CAP laboratory guidelines

  • GMP-compatible environments


Alternative Equipment

  • Manual library preparation kits

  • Automated liquid handling systems

  • NGS sequencing instruments

  • Library QC and quantification systems


Final Summary 

Automated NGS System NNGS-101 is a high-performance laboratory automation platform designed to streamline DNA and RNA library preparation for next-generation sequencing. It improves workflow efficiency, reduces manual error, and supports scalable genomic research across clinical, pharmaceutical, and biotechnology applications.

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